Articular Mobility | Synergia

Articular Mobility

Joint diseases affect more than 10 million French people. The most frequent is osteoarthritis caused by the wear and tear of joints. This wear and tear is mainly age-related, but prematurely affects traumatic occupations and top-level athletes. Today on the market, there are two types of products dealing with these problems. On the one hand, painkillers which are very effective for eliminating temporarily the pain. But, on the flip side, everyone knows that you should not abuse painkillers and that it is dangerous to consume them in in excessive quantities on a daily basis. On the other hand, slow-acting drugs in osteoarthritis (chondroitin, glucosamine) which have never really convinced neither health professionals, nor patients. Considered inadequate by the French National Authority for Health, they have been delisted (1). Yet, there is another innovative solution: immunological oral tolerance (2).

What is the Mechanism of Immunological Oral Tolerance?

Joint wear and tear creates joint inflammation that is often accompanied by pain. Why?  When there is inflammation, the immune system mobilises around the joint tissue with an aggressive attitude. This attitude of the immune system self-sustains the inflammation which thus gradually worsens the situation, making osteoarthritis a chronic disease. Oral tolerance is a mechanism which allows to reverse the attitude of the immune system, in order to obtain an anti-inflammatory and reconstructive action. This same totally natural mechanism is successfully used by allergists for carrying out allergic desensitisation. As a matter of principle, the allergy is an aggressive reaction of the immune system against the allergen, causing in the patient all the sufferings that are known. By administering a very small dose of the allergen repeatedly to the allergic patient, the immune system will modify its reaction and definitively accept this substance and consider it a friend. The patient will therefore be desensitised.

The Interest of Type II Collagen in Food Supplementation

In the case of osteoarthritis, type II collagen in the joint is targeted by the immune system (TH1 white blood cells) exactly as in the allergy. By administering very small quantities of type II collagen, we can obtain from the immune system (TH1 cells) an anti-inflammatory and reconstructive action. It has the advantage of being easily bearable and not presenting any undesirable side effect. Thus, the pain will significantly reduce with progress in mobility. Indeed, twenty years of chemical studies show an improvement after 40 days on average with success in 70% of cases (3). To know whether you can benefit from joint improvement, simply take a very small dose of type II collagen for 90 days. In case of failure, quite simply stop taking it; in case of success, continue taking it on an ongoing basis.

Our Advice

It is recommended to supplement with a “dermo-joint” gel which will act immediately by soothing your joints. This massage gel, with its immediate action, allows for immunological oral tolerance to be implemented.

Bibliography: (1) Commission de Transparence de la Haute Autorit. de Sant., Avis du 20 novembre 2013. (2) Oral type II collagen treatment in early rheumatoid arthritis a double-blind, placebo-controlled, randomized trial. Joachim Sieper, Sonja Kary, Helmut Sorensen, Rieke Alten, Ulrich Eggens, Werner Huge, Falk Hiepe, Andrea Kuhne, Joachim Listing, Norbert Ulbrich, Jurgen Braun, Angela Zink, and Nicholas Avrion Mitchison. Source : Arthritis & Rheumatism Vol. 39. No 1 Janvier 1996, pp 41-51. (3) Effects of oral administration of type II collagen on rheumatoid arthritis. David E. Trentham, Roselynn A. Dynesius-Trentham, E. John Orav, Daniel Combitchi, Carlos Lorenzo, Kathryn Lea Sewell, David A. Hafler, Howard L. Weiner. Source: Science, New Series, Vol. 261, No 5129 (24 Sept. 1993), pp. 1727-173.


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